Light propagation along the pericardium meridian at human wrist as evidenced by the optical experiment and Monte Carlo method / 中国结合医学杂志

<p><b>OBJECTIVE</b>To explore the characteristics of light propagation along the Pericardium Meridian and its surrounding areas at human wrist by using optical experiment and Monte Carlo method.</p><p><b>METHODS</b>An experiment was carried out to obtain the distribution of diffuse light on Pericardium Meridian line and its surrounding areas at the wrist, and then a simplified model based on the anatomical structure was proposed to simulate the light transportation within the same area by using Monte Carlo method.</p><p><b>RESULTS</b>The experimental results showed strong accordance with the Monte Carlo simulation that the light propagation along the Pericardium Meridian had an advantage over its surrounding areas at the wrist.</p><p><b>CONCLUSION</b>The advantage of light transport along Pericardium Merdian line was related to components and structure of tissue, also the anatomical structure of the area that the Pericardium Meridian line runs.</p>

Protective effect of oligosaccharides from Morinda officinalis on beta-amyloid-induced dementia rats / 中国中药杂志

<p><b>OBJECTIVE</b>To observe the effect of oligosaccharides of Morinda officinalis (OMO) on beta-amyloid-induced dementia rats, and study its pharmacological mechanism in treatment of dementia.</p><p><b>METHOD</b>The dementia model rats were established by injecting Abeta25-35 10 microLg into bilateral hippocampus. OMO high-dose (60 mg . kg-1 . d-1) group, OMO low-dose (20 mg . kg-1 . d-1 ) groups, the blank group, the sham operation group and the positive donepezil HC1 group (0. 125 mg kg-1 . d-1) were designed for the experiment. They were continuously administered with drugs at the 15th day after operation for 25 days. Kit microplate method was used to detect the contents of super oxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione reductase (GSH-Px), acetylcholine (ACh) , acetylcholinesterase (AChE) and Na+ /K+ -ATPase.</p><p><b>RESULT</b>Compared with the model group, all of administration groups showed higher SOD, CAT and GSH-Px levels, and lower MDA in the brain tissues. Besides, they also showed rise in the activities of ACh and Na+ /K+ -ATPase.</p><p><b>CONCLUSION</b>OMO can ameliorate on beta-amyloid-induced dementia rats by enhancing oxidation resistance, activating brain energy metabolism and improving the injury of cholinergic system.</p>

Research on the effect of light and heat sensing along meridian of Chinese medicine

Photonics refers to the technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. Photonic technology in the meridian and acupoints research has shown the unique advantages, by which the microcosmic material basis and macroscopic phenomena research can be integrated to interpret the occurrence of propagated sensation along meridian [PSM] and its underlying mechanism. This study seeks to investigate light and heat sensing action along meridian. From the modern research of meridian point of view, PSM is the break point to research the essentiality of meridian. The bio-photonic feature of meridian is the most promising research direction to investigate the PSM phenomena for its contribution to prove the existence of meridian objectively and spontaneously. Therefore, the bio-photonic features of meridian under physiological, pathological, therapeutic, and mechanical conditions were analyzed. Firstly, the four aspects of light sensing action were discussed, i.e. light sensing effect along meridian, blocking effect, laser induced effect and underlying mechanism of light sensing action along meridian. Secondly, the four items of heat sensing action were discussed as well, i.e. thermo-effects, heat perception ability, laser induced heat effect, underlying mechanism on heat sensing effect along meridian. The authors point out that photonic technology, e.g. ultra-weak luminescence, photonic imaging, infrared imaging and infrared spectrum analysis, biological photons detection and laser Doppler application, can achieve purposes of in vivo, dynamic, multiple comparable studies. Thereby, the effect of light and heat sensing along meridian can be detected and illustrated by the use of natural science. The effect of light sensing and heat sensing along meridians with the help of advantages of photonics is expected to interpret and quantify the meridian doctrine, to provide an important experimental basis for meridians and acupoint properties of light and heat, to find a kind of non-invasive diagnostic technique, and to promote the integration and development of meridians and modern medicine. Light and heat information can be investigated to analyze the relationship between zang-fu organs and meridians, and the functional characteristics of the meridian. Hence, the effect of light and heat sensing along meridian is the break point of the research of photonics in meridian, which is beneficial to further study the meridian optics

Optical transport properties along the pericardium meridian under different pressure

This study seeks to discuss the light wave transport characteristics variation along the pericardium Meridian under different pressures. We selected 36 healthy students at the school for this study, tied up the desktop blood pressure cuff onto subjects'right proximal arms, fixed the detection probe immovably on the Neiguan [PC6] acupoint and the reference point which was 1cm off the PC6, and collected the light signal along the meridian and non-meridian when the laser irradiate Jianshi[PC5], Ximen[PC4] and the corresponding reference points respectively under pressure of 0, 100, 130 and 160. The differences in optical transport properties between meridian and nonmeridian were significant: under the same pressures [0s, 100s,130s, and 160mmHg], the relative attenuation rate of optical signal at the same distance between meridian and non-meridian were significant[p<0.001], the optical signal attenuates slower when it transported along meridians; however, there is no significant difference for the relative attenuation rate of optical signal along meridian or non-meridian under different pressures[p>0.05]. Under four different pressure situations, the optical signal at acupoint[PC5] and non-acupoint[NP] along the meridian were significantly different with the corresponding reference points along the non-meridian[P<0.001]; the optical signal on the meridian is stronger than the non-meridian one; the optical signals are strikingly different at acupoints, non-acupoints, and reference points between and 100, 130, and 160mmHg pressures [P

Effect and safety evaluation of catgut implantation at acupoint for levels of bone metabolism and free radicals in postmenopausal women / 中国针灸

<p><b>OBJECTIVE</b>To compare the effect and safety evaluation of catgut implantation at acupoint and drugs for levels of bone metabolism and free radicals in postmenopausal women.</p><p><b>METHODS</b>Sixty-five postmenopausal women were randomly divided into an acupoint catgut implantation group (33 cases) and a medication group (32 cases). Sanyinjiao (SP 6), Shenshu (BL 23) and Guanyuan (CV 4) were used as main points combined with adjunct points according to syndrome differentiation in the acupoint catgut implantation group, once two weeks. The medication group was treated with oral administration of 2 pills of Fu fuchun capsule, once a day. Three months constitute one course in the both groups. The scores of the symptoms and signs were evaluated, and elbow vein blood was drawn to detect the correlative index on the beginning and the ending day of the treatment respectively. The safety of catgut implantation at acupoint was evaluated after one course of treatment. Besides, the sex hormone test in ovulatory period was detected in twenty-eight normal women in reproductive age with regular menstrual cycle.</p><p><b>RESULTS</b>1) The total effective rate of the acupoint catgut implantation group was 93.9% (31/33), and that of the medication group was 96.9% (31/32), there was no significant difference between the two groups (P>0.05). The contents of bone gla protein (BGP), calcitonin (CT), parathyroid hormone (PTH) and alkaline phosphatase (AKP) in the both groups had significant differences after treatment (P<0.05, P<0.01); 2) The content of estradiol (E2) in serum in the both groups was decreased more obviously than those of normal women in reproductive age (both P<0.001). The content of E2 in the both groups was obviously increased after treatment (P<0.05, P<0.01), this function in the acupoint catgut implantation group was weaker than that of the medication group (P<0.05), while the incidence rate of adverse effect in the acupoint catgut implantation group was lower than that of the medication group (P<0.05); 3) There were significant differences of the level of superoxide dismutase (SOD) and malondialdehyde (MDA) before and after treatment in the acupoint catgut implantation group, the level of SOD was obviously increased after treatment (P<0.01), while the level of MDA decreased obviously (P<0.001).</p><p><b>CONCLUSION</b>Catgut implantation at acupoint can improve the low level of estrogen of postmenopausal women, with good safety. It can regulate the levels of bone metabolism and free radicals of postmenopausal women, so it is very meaningful to prevent and treat postmenopausal degenerative diseases including the osteoporosis and to delay the process of apolexis.</p>

Effect of acupoint catgut-embedding on the quality of life, reproductive endocrine and bone metabolism of postmenopausal women / 中国结合医学杂志

<p><b>OBJECTIVE</b>To observe the influence of acupoint catgut-embedding therapy on the quality of life (QOL), the reproductive endocrine and bone metabolism of postmenopausal women.</p><p><b>METHODS</b>A total A total of 65 women with climacteric syndrome were enrolled and randomly assigned to two groups, thirty-three in the treatment group on whom acupoint catgut-embedding was performed with Shenshu (BL23), Sanyinjiao (SP6) and Guanyuan (CV4) as main acupoints, and thirty-two in the control group who were only medicated with Fufuchun Capsule (妇复春胶囊). The treatment course for both groups was 3 months. Before and after Before and after treatment, the clinical symptoms, the QOL score, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E(2)), testosterone (T), osteocalcin (BGP), parathyroid hormone (PTH), calcitonin (CT) and alkaline phosphatase (AKP) were measured. In addition, another 28 women with childbearing potential and normal regular menstrual cycle were selected and the reproductive endocrine hormone were tested in the ovulatory period as controls.</p><p><b>RESULTS</b>The levels of serum FSH and LH of postmenopausal women were higher, and serum E(2) and T were lower than those of normal women (P<0.01). After treatment, the levels of serum E(2) In both groups and T in the treatment group were increased, while in the control group the serum E(2) increase was more significant than that in the treatment group (P<0.05), and serum T showed no statistical difference. The levels of serum FSH, LH, BGP, CT, PTH and AKP were reduced significantly in both groups after treatment (P<0.05). The QOL scores were Increased remarkably in both groups on physiological functioning, bodily pain, general health, vitality, and mental health after treatment (P<0.05),but the improvement of bodily pain and mental health in the treatment group were better than those in the control group (P<0.01). There was no significant difference in the therapeutic effect between the two groups after treatment (P>0.05).</p><p><b>CONCLUSIONS</b>Acupoint catgut-embedding showed an obvious effect on climacteric syndrome, and enhanced the QOL in postmenopausal women. The therapy could regulate the hypothalamic-pituitary-ovarian axis to raise the serum E(2) level which may be significant in preventing and curing the osteoporosis in postmenopausal women.</p>

Activated brain areas during simple and complex mental calculation--a functional MRI study / 生理学报

Functional magnetic resonance imaging (fMRI) was used to study the activated brain areas of human during simple and complex digital calculation, and to investigate the role of cortical and subcortical structures involved in the mental calculation. Sixteen right-handed healthy volunteers performed mental calculation of simple and complex addition/subtraction respectively, while the fMRI data were recorded by a Seimens 1.5 T MR machine. Block-design was used in the tasks. Two calculation tasks and one base-line tasks were performed for the block-design. Simple calculation task was single-digit addition and subtraction, while the complex was multi-digit addition and subtraction. The base-line task was to tell whether the two numbers were the same in every trial. Statistical parametric mapping (SPM99) was employed to process data and localize functional areas. We compared the average activation intensity of each activated brain regions in the same calculation task and the activation intensity of the same regions in both tasks respectively. Both the cortex and the subcortical structures including basal ganglia and thalamus were activated during simple and complex mental calculations. Similar brain regions in subjects including frontal lobe, parietal lobe, occipital lobe, cingulate gyrus, thalamus and cerebellum were engaged in simple and complex addition/subtraction. In the same task, activation intensity of all activated brain areas differed insignificantly. Compared with the complex task, the right parietal lobe was not activated in the simple one. The subcortical structures such as the caudate nucleus and the left marginal division of the striatum (MrD) were activated in both two calculation tasks. The cortical regions involved in both simple and complex addition/subtraction were similar. In conclusion, both the cortex and the subcortical structures were activated during the mental calculation. The cortex including the frontal cortex, parietal cortex, and cingulate gyrus were activated during mental calculation, while the subcortical structures such as the caudate nucleus, the globus pallidum and the left marginal division of the striatum also played a critical role in the neural networks of the calculation at the same time. Right parietal lobe (supramarginal gyrus) was engaged only in the complex task, which suggested that this region might be involved in the visuospatial memory and processing.